Southampton are the side tasked with halting that run, and they too will be confident of coming away from this fixture with maximum points.
The Saints have won their last three home league matches by the same 2-0 scoreline and could win four in a row at St Mary’s for the first time since May 2016.
Ralph Hasenhuttl has rightly earned plenty of praise for his work on the South Coast, with Southampton recently topping the table for the first time in 32 years.
Last week’s 1-1 draw with Wolverhampton Wanderers saw them slip down to fifth, but this match presents another opportunity to show just how far they have come under the Austrian.
Southampton Premier League form: WDWWWD
Manchester United Premier League form: LWDLWW
Manchester United form (all competitions): WLLWWW
Man United defenders Aaron Wan-Bissaka and Victor Lindelof picked up knocks in midweek and will be assessed, while Eric Bailly and Phil Jones are also nursing injuries.
Solskjaer has a big call to make up top given Anthony Martial’s lack of form through the middle, which could see Edinson Cavani leading the line after his start against Basaksehir.
Paul Pogba is still struggling for fitness, leaving Scott McTominay, Nemanja Matic, Fred and Donny van de Beek to battle it out for the two holding-midfield berths.
As for Southampton, Nathan Redmond has been ruled out because of a troublesome injury that has restricted him to three league starts all season.
Ryan Bertrand and James Ward-Prowse recovered from injuries to start against Wolves on Monday and should be involved from the start here.
There is still no Danny Ings for the Saints, but Theo Walcott is back among the goals and is looking to score his fourth career goal against United, each at a different ground.
Southampton possible starting lineup:
McCarthy; Walker-Peters, Bednarek, Vestergaard, Bertrand; Armstrong, Ward-Prowse, Romeu, Djenepo; Adams, Walcott
Manchester United possible starting lineup:
De Gea; Wan-Bissaka, Tuanzebe, Maguire, Telles; McTominay, Matic; Greenwood, Fernandes, Rashford; Cavani